As a member of the Chaaban laboratory, Dr. Burge focuses on developing experimental models, particularly in vitro, through which to study diseases of intestinal inflammation. A recent focus has included mechanisms through which glycosaminoglycans (GAGs) may protect against necrotizing enterocolitis, an inflammatory condition affecting predominantly preterm infants. Primary 3D organoids, 2D organoid-derived monolayers, and rodent models of NEC are utilized to interrogate mechanistic functions of GAGs in this and related contexts.
PhD: Baylor University, Department of Biology, Waco, TX
Postdoctoral Fellowship: University of Central Florida College of Medicine, Orlando, FLrsity, Department of Biology, Waco, TX
The Chaaban laboratory works to elucidate the mechanisms through which glycosaminoglycans (GAGs), biologically active components of breast milk, may be protective against intestinal inflammation generally, and neonatal necrotizing enterocolitis (NEC), in particular. Research in the Chaaban laboratory has focused on the many risk factors at play in predisposing infants to developing NEC, including extensive use of antibiotics, lack of breastfeeding, disrupted intestinal microbiome, and the developmentally immature interface between the immune system and the intestinal epithelium in the neonate. Both rodent models and in vitro systems are utilized to further investigate specific attributes of many of these risk factors in the hope that effective therapeutic strategies against NEC and associated diseases will surface.
Select Honors & Accomplishments:
2013 - Great Lakes National Scholarship Award Winner
2012 - Great Lakes National Scholarship Award Winner
2011 - Baylor University Folmar Grant Award
2010 - Baylor University Folmar Grant Award
2009 - Baylor University Graduate Student Award Presentation
2006 - Beta Beta National Biological Honor Society
2002-2006 - Illinois Wesleyan University Merit Scholarship
2004 - NSF Research Experience for Undergraduates (REU)
- Chaaban H, Burge K, Eckert J, Keshari R, Silasi-Mansat R, Lupu C, Warner B, Escobedo M, Caplan M, Lupu F. Neutrophil extracellular trap inhibition increases inflammation, bacteremia, and mortality in murine necrotizing enterocolitis. J Cell Molec Med (Online Ahead of Print), 2020. PMID 32515131
- Gunasekaran A, Eckert J, Burge K, Zheng W, Yu Z, Kessler S, de la Motte C, Chaaban H. Hyaluronan 35 kDa enhances epithelial barrier function and protects against the development of murine necrotizing enterocolitis. Ped Res 87(7), 177-1184, 2019. PMID 31499514. PMC7061074
- Burge KY, Hannah L, Eckert JV, Gunasekaran A, Chaaban H. The protective influence of chondroitin sulfate, a component of human milk, on intestinal bacterial invasion and translocation. J Human Lactation 35(3):538-549, 2019