Ph.D., CSIR-Institute of Genomics and Integrative Biology (CSIR-IGIB), Delhi, India
Postdoctoral Research Associate., University of Nebraska Medical Center, Nebraska, USA
- Metabolic regulation of immune cells in tumor microenvironment
- Immune cell crosstalk at the primary tumor site and systemic microenvironments
- Developing novel immunotherapies and therapeutic combinations for pancreatic cancer
- Interrogate the role of immune players in cancer cachexia
- Pancreatic cancer
King RJ, Shukla SK, He C, Vernucci E, Thakur R, Attri KS, Dasgupta A, Chaika NV, Mulder SE, Abrego J, Murthy D, Gunda V, Pacheco CG, Grandgenett PM, Lazenby AJ, Hollingsworth MA, Yu F, Mehla K#, Singh PK# (# Co-corresponding author). CD73 induces GM-CSF/MDSC-mediated suppression of T cells to accelerate pancreatic cancer pathogenesis. Oncogene. 2022 Feb;41(7):971-982. doi: 10.1038/s41388-021-02132-6.
King RJ, Singh PK, Mehla K. The cholesterol pathway: impact on immunity and cancer. Trends Immunol. 2022 Jan;43(1):78-92. doi: 10.1016/j.it.2021.11.007.
Markov SD, Caffrey TC, O'Connell KA, Grunkemeyer JA, Shin S, Hanson R, Patil PP, Shukla SK, Gonzalez D, Crawford AJ, Vance KE, Huang Y, Eberle KC, Radhakrishnan P, Grandgenett PM, Singh PK, Madiyalakan R, Daniels-Wells TR, Penichet ML, Nicodemus CF, Poole JA, Jaffee EM, Hollingsworth MA, Mehla K. IgE-Based Therapeutic Combination Enhances Antitumor Response in Preclinical Models of Pancreatic Cancer. Mol Cancer Ther. 2021 Dec;20(12):2457-2468.
Shukla SK, Markov SD, Attri KS, Vernucci E, King RJ, Dasgupta A, Grandgenett PM, Hollingsworth MA, Singh PK, Yu F, Mehla K. Macrophages potentiate STAT3 signaling in skeletal muscles and regulate pancreatic cancer cachexia. Cancer Lett. 2020 Aug 1;484:29-39.
Mehla K, Singh PK. Metabolic Regulation of Macrophage Polarization in Cancer. Trends Cancer. 2019 Dec;5(12):822-834.
Complete List of Published Work: