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Je-Hyun Yoon, PhD
Oncology Science

Je-Hyun Yoon, PhD

Associate Professor

941 Stanton L. Young Blvd., Oklahoma City, OK 73104

405.271.8001 Ext. 32905

Academic Section(s):

Oncology Science


Ph.D., University of Arizona, Tucson, AZ, US

Postdoctoral Training, National Institute on Aging/National Institutes of Health, Baltimore, MD, US

Clinical/Research Interests:

  • The alcoholic liver injury and cancer studies involving extracellular RNA release
  • The Duchenne Muscular Dystrophy studies focusing on circular RNA biogenesis
  • Post-transcriptional RNA modifications by small peptides in energy metabolism

Dr. Yoon's main research interest is understanding the “RNP Code”, that is, the composition and function of RNA-binding proteins bound to RNAs, both coding and noncoding. He has contributed to efforts to characterize the assembly, composition, and function of ribonucleoprotein (RNP) particles, the influence of long noncoding (lnc)RNAs in translation and ubiquitin-mediated proteolysis, and the mechanisms that determine lncRNA abundance in the cell. He is interested in elucidating the rules that govern the assembly of RBPs into RNA-containing functional complexes, the influence of signaling events that regulate RNPs, and the impact of specific RBPs and RNAs on RNP activity and ensuing gene regulation. He is specifically interested in studying the consequences of RNPs on cellular events such as proliferation, survival, senescence, aging and age-associated human diseases such as cancer.

Currently recruiting new students and trainees.

Select Publications:

Park MK, Zhang L, Min KW, Cho JH, Yeh CC, Moon H, Hormaechea-Agulla D, Mun H, Ko S, Lee JW, Jathar S, Smith AS, Yao Y, Giang NT, Vu HH, Yan VC, Bridges MC, Kourtidis A, Muller F, Chang JH, Song SJ, Nakagawa S, Hirose T, Yoon JH*, Song MS*.

NEAT1 is essential for metabolic changes that promote breast cancer growth and metastasis.

Cell Metab. 2021 Dec 7;33(12):2380-2397.e9. doi: 10.1016/j.cmet.2021.11.011.

(*Co-corresponding authors)

PMID: 34879239; PubMed Central PMCID: PMC8813003


Lee TA, Han H, Polash A, Cho SK, Lee JW, Ra EA, Lee E, Park A, Kang S, Choi JL, Kim JH, Lee JE, Min KW, Yang SW, Hafner M, Lee I, Yoon JH*, Lee S*, Park B*.

The nucleolus is the site for inflammatory RNA decay during infection.

Nat Commun. 2022 Sep 3;13(1):5203. doi: 10.1038/s41467-022-32856-2.

(*Co-corresponding authors)

PMID: 36057640; PubMed Central PMCID: PMC9440930


Sun Q, Tripathi V*, Yoon JH*, Singh DK, Hao Q, Min KW, Davila S, Zealy RW, Li XL, Polycarpou-Schwarz M, Lehrmann E, Zhang Y, Becker KG, Freier SM, Zhu Y, Diederichs S, Prasanth SG, Lal A, Gorospe M, Prasanth KV*.

MIR100 host gene-encoded lncRNAs regulate cell cycle by modulating the interaction between HuR and its target mRNAs.

Nucleic Acids Res. 2018 Nov 2;46(19):10405-10416. doi: 10.1093/nar/gky696.

(*Co-corresponding authors)

PubMed PMID: 30102375; PubMed Central PMCID: PMC6212728.


Min KW, Zealy RW, Davila S, Fomin M, Cummings JC, Makowsky D, Mcdowell CH, Thigpen H, Hafner M, Kwon SH, Georgescu C, Wren JD*, Yoon JH*.

Profiling of m6A RNA modifications identified an age-associated regulation of AGO2 mRNA stability.

Aging Cell. 2018 Jun;17(3):e12753. doi: 10.1111/acel.12753.

(*Co-corresponding authors)

PubMed PMID: 29573145; PubMed Central PMCID: PMC5946072.


Min KW, Jo MH, Shin S, Davila S, Zealy RW, Kang SI, Lloyd LT, Hohng S*, Yoon JH*.

AUF1 facilitates microRNA-mediated gene silencing.

Nucleic Acids Res. 2017 Jun 2;45(10):6064-6073. doi: 10.1093/nar/gkx149.

(*Co-corresponding authors)

PubMed PMID: 28334781; PubMed Central PMCID: PMC5449627.


Yoon JH, Jo MH, White EJ, De S, Hafner M, Zucconi BE, Abdelmohsen K, Martindale JL, Yang X, Wood WH 3rd, Shin YM, Song JJ, Tuschl T, Becker KG, Wilson GM, Hohng S, Gorospe M.

AUF1 promotes let-7b loading on Argonaute 2.

Genes Dev. 2015 Aug 1;29(15):1599-604. doi: 10.1101/gad.263749.115.

PubMed PMID: 26253535; PubMed Central PMCID: PMC4536308.


Yoon JH, De S, Srikantan S, Abdelmohsen K, Grammatikakis I, Kim J, Kim KM, Noh JH, White EJ, Martindale JL, Yang X, Kang MJ, Wood WH 3rd, Noren Hooten N, Evans MK, Becker KG, Tripathi V, Prasanth KV, Wilson GM, Tuschl T, Ingolia NT, Hafner M, Gorospe M.

PAR-CLIP analysis uncovers AUF1 impact on target RNA fate and genome integrity.

Nat Commun. 2014 Nov 4;5:5248. doi: 10.1038/ncomms6248.

PubMed PMID: 25366541; PubMed Central PMCID: PMC4291169.


Yoon JH, Abdelmohsen K, Srikantan S, Guo R, Yang X, Martindale JL, Gorospe M.

Tyrosine phosphorylation of HuR by JAK3 triggers dissociation and degradation of HuR target mRNAs.

Nucleic Acids Res. 2014 Jan;42(2):1196-208. doi: 10.1093/nar/gkt903. Epub 2013 Oct 7.

PubMed PMID: 24106086; PubMed Central PMCID: PMC3902907.


Yoon JH, Abdelmohsen K, Kim J, Yang X, Martindale JL, Tominaga-Yamanaka K, White EJ, Orjalo AV, Rinn JL, Kreft SG, Wilson GM, Gorospe M.

Scaffold function of long non-coding RNA HOTAIR in protein ubiquitination.

Nat Commun. 2013;4:2939. doi: 10.1038/ncomms3939.

PubMed PMID: 24326307; PubMed Central PMCID: PMC4556280.


Yoon JH, Abdelmohsen K, Srikantan S, Yang X, Martindale JL, De S, Huarte M, Zhan M, Becker KG, Gorospe M.

LincRNA-p21 suppresses target mRNA translation.

Mol Cell. 2012 Aug 24;47(4):648-55. doi: 10.1016/j.molcel.2012.06.027. Epub 2012 Jul 26.

PubMed PMID: 22841487; PubMed Central PMCID: PMC3509343.


Yoon JH, Choi EJ, Parker R.

Dcp2 phosphorylation by Ste20 modulates stress granule assembly and mRNA decay in Saccharomyces cerevisiae.

J Cell Biol. 2010 May 31;189(5):813-27. doi: 10.1083/jcb.200912019.

PubMed PMID: 20513766; PubMed Central PMCID: PMC2878948.