Education:
Ph.D., University of Calcutta, Kolkata, India.
Postdoctoral Training, Washington University School of Medicine, St. Louis, USA.
Clinical/Research Interests:
Mechanisms underlying radiation-induced T cell lymphopenia in glioblastoma and head and neck squamous cell carcinoma
How regulatory myeloid cells play a role in therapeutic resistance in solid tumors.
Select Publications:
Ghosh S, Johanns TM, Chheda MG, Liu E, Butt O, C Abraham C, Badiyan S, Huang Y, DeNardo D, Kim AH, Hallahan D, Thotala D, Huang J. A pilot phase 1B study to evaluate tadalafil to overcome immunosuppression during chemoradiotherapy for IDH-wildtype glioblastoma. Neuro-Oncology-Advances. 2023;5(1).
Ghosh S, Huang J, Inkman M, Zhang J, Thotala S, Tikhonova E, Miheecheva N, Frenkel F, Ataullakhanov R, Wang X, DeNardo D, Hallahan D, Thotala D. Radiation-induced circulating myeloid-derived suppressor cells induce systemic lymphopenia after chemoradiotherapy in patients with glioblastoma. Science Translational Medicine. 2023;15(680):eabn6758.
Chen L, Shi V, Wang S, Freeman R, Inkman M, Ghosh S, Ruiz F, Jayachandran K, Huang Y, Luo J, Zhang J, Cosper P, Luke CJ, Spina CS, Grigsby PW, Schwarz JK, Markovina S. SCCA1/SERPINB3 suppresses antitumor immunity and blunts therapy-induced T cell responses via STAT-dependent chemokine production. Journal of Clinical Investigation. 2023;133(15).
Campian JL#, Ghosh S#, Kapoor V, Yan R, Thotala S, Jash A, Hu T, Mahadevan A, Rifai K, Page L, Lee BH, Ferrando-Martinez S, Wolfarth AA, Yang SH, Hallahan D, Chheda MG, Thotala D. Long-Acting Recombinant Human Interleukin-7, NT-I7, Increases Cytotoxic CD8 T Cells and Enhances Survival in Mouse Glioma Models. Clinical Cancer Research. 2022;28(6):1229-39. (# Co-first authors)