Office
Stephenson Cancer Center - Suite #L100
800 N.E 10th Street, Oklahoma City, OK 73104. USA.
Voice: (405) 271-3825; Fax: (405) 271-3820
Laboratory
Biomedical Sciences Building (BMSB) Rooms 737 &741
940 Stanton L. Young Boulevard,
Oklahoma City, OK 73104. USA.
Voice: (405) 271-8000 Ext-47787, 41423, 41424
Education:
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Andhra University, Erskine College of Natural Sciences, Visakhapatnam, India Ph.D. (2000)
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Radiation Biology, Department of Radiation Oncology, University of Texas Health Science Center at San Antonio, TX Postdoctoral Fellow (2001)
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Critical Care Medicine, Division of Anesthesiology and Pain Medicine, UT M.D. Anderson Cancer Center, Houston, TX Postdoctoral Fellow (2005)
Clinical/Research Interests:
Radiation biology – cancer cell acquired radioresistance, approaches for radiosensitization and cancer cure, and space (galactic) radiation in carcinogenesis, cardiovascular complications
Signaling in therapy resistance and cancer evolution - extra cranial pediatric (neuroblastoma) and solid (breast, renal, pancreatic) cancers
Developmental therapeutics – novel phytochemicals and approaches for cancer cure, radioprotection.
Select Honors & Accomplishments:
- Fellowships from the Indian Council of Agricultural Research (ICAR), Government of India (1996-2000)
- Member, Cancer Biology Program, Stephenson Cancer Center
- Faculty, OUHSC Graduate College
- Member, Oklahoma Center for Neuroscience
- Member, Pathology Graduate Committee
Select Publications:
Peer Reviewed Publications
Peer Reviewed Published Abstracts
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Somasundaram DB, Subramanian K, Aravindan S, Yu Z, Natarajan M, Herman TS and Aravindan N. 2019. De novo regulation of RD3 synthesis in residual neuroblastoma cells after intensive multi-modal clinical therapy harmonizes disease evolution. Nature - Sci Rep. 13;9(1):11766. doi: 10.1038/s41598-019-48034-2. PMID: 31409909
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Aravindan N, Aravindan S, Manickam K and Natarajan M. 2016. High Energy Particle Radiation-associated Oncogenic Transformation in Normal Mice: Insight into the Connection between Activation of Oncotargets and Oncogene Addiction. Nature – Sci Rep. 6:37623. 27876887
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Natarajan M, Aravindan N, Sprague EA, Mohan S. 2016. Hemodynamic Flow-Induced Mechanotransduction Signaling Influences the Radiation Response of the Vascular Endothelium. Radiat Res. 186(2):175-88. PMID: 27387860
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Ramraj S, Aravindan S, Somasundaram DB, Herman TS, Natarajan M and Aravindan N. 2016. Serum-circulating miRNAs predict neuroblastoma progression in mouse model of high-risk metastatic disease Oncotarget. PMID: 26921195
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Aravindan S, Ramraj S, Natarajan M, Herman TS, Somasundaram ST and Aravindan N. 2015. Polyphenols from marine brown algae target radiotherapy-coordinated EMT and stemness-maintenance in residual pancreatic cancer. BMC Stem Cell Res & Ther.6(1):182. PMID: 26395574.
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Khan FH, Pandian V, Ramraj S, Azadi S, Aravindan S, Natarajan M, Herman TS and Aravindan N. 2015. RD3 loss dictates high-risk aggressive neuroblastoma and poor clinical outcomes. Oncotarget 6(34): 36522-36534. PMID: 26375249.
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Pandian V, Ramraj S, Khan FH, Azim T and Aravindan N. 2015. Metastatic neuroblastoma cancer stem cells exhibit flexible plasticity and adaptive stemness signaling. BMC – Stem Cell Research and Therapy. 6(1):2. PMID: 25888913
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Aravindan N, Aravindan S, Pandian V, Khan FH, Ramraj SK, Natt P, Natarajan M. 2014. Acquired tumor cell radiation resistance at the treatment site is mediated through radiation-orchestrated intercellular communication. Int J Radiat Oncol Biol Phys., 88(3):677-85, PMID: 24411622.
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Aravindan S, Natarajan M, Ramraj SK, Pandian V, Khan FH, Herman TS, Aravindan N. 2014. Abscopal effect of low-LET γ-radiation mediated through Rel protein signal transduction in a mouse model of non-targeted radiation response. Nature-Cancer Gene Ther., 21(2):54-9. PMID: 24357814.
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Veeraraghavan J, Natarajan M, Aravindan S, Herman TS and Aravindan N. 2011 Radiation triggered TNFa-NFkB cross signaling favors survival