Education:
Fellowship: 1993-1995, Genetic Epidemiology, Graduate School of Public Health, University of Pittsburgh, PA
Fellowship: 1992-1993, Molecular Mutagenesis, Graduate School of Public Health, University of Pittsburgh, PA
Ph. D.: 1992, Human Genetics, Guru Nanak Dev University, Amritsar, India
Clinical/Research Interests:
Dr. Dharambir Sanghera, Ph.D., FAHA is the director of the Genetic Epidemiology Laboratory at the University of Oklahoma Health Sciences Center (OUHSC). Dr. Sanghera’s health disparity research specializes in molecular and genetic epidemiological aspects of complex diseases, with a special focus on Type 2 Diabetes, Obesity, Coronary Artery Disease, Stroke, and Dyslipidemia. She is Director and Principal Investigator of the Sikh Diabetes Study (SDS)/Asian Indian Diabetic Heart Study (AIDHS) and has over 25 years of experience in conducting large clinical genetic studies funded through NIH and foundation grants. She is also the principal investigator of the Metabolome in Ischemic Stroke Study (MISS) to identify biomarkers of Stroke in Oklahoma with Co-PI Dr. Evgeny Sidorov from the Department of Neurology at OUHSC.
Dr. Sanghera's laboratory is employing genome-wide linkage, genome-metabolome-wide association, and linkage disequilibrium approaches on family‐ and population‐based datasets and is also examining the functional role of novel variants with insulin resistance, and hyperlipidemia using zebrafish and cell model systems. The long‐term goals of Dr. Sanghera’s research are; 1) to identify the underlying molecular mechanisms associated with these disorders, 2) to improve the classification of the disease process by identifying genome‐wide patterns associated with the ethnic variation, and 3) to discover new gene‐based targets based on ethnic origin and environmental and cultural differences which can inform the design of early prevention and treatment therapy among immigrant populations.
Select Publications:
http://www.ncbi.nlm.nih.gov/pubmed/?term=dharambir+sanghera