Dr. Mathias’ research focuses on the growth and function of pulmonary blood vessels in the fetus and newborn. Preterm birth and exposure to lifesaving therapies in the NICU disrupt normal development of the lung and its blood vessels. Dr. Mathias aims to identify mechanisms underlying this abnormal development that can be targeted for prevention or mitigation of bronchopulmonary dysplasia (BPD) and BPD-associated pulmonary hypertension. His clinical interests are the management of severe bronchopulmonary dysplasia and associated pulmonary vascular disease, including home mechanical ventilation.
Languages Spoken: English
Fun Fact: "I have an Australian Cattle Dog named Rosalind Franklin."
Academic Section(s):
Neonatal-Perinatal Medicine
Education:
MD - Icahn School of Medicine at Mount Sinai, New York, New York
Residency - Icahn School of Medicine at Mount Sinai, New York, New York
Fellowship - Northwestern University/Lurie Children’s Hospital, Chicago, Illinois
Board Certification(s):
American Board of Pediatrics (2018 - present)
Neonatal-Perinatal Medicine (2021 - present)
Clinical/Research Interests:
Specifically, Dr. Mathias researches the role of redox modifications to protein tyrosine phosphatases (PTPs) in pulmonary vascular development. Many vascular growth factors function by inducing receptor autophosphorylation. PTPs can dephosphorylate growth factor receptors and modify downstream signaling. These redox sensitive proteins are transiently oxidized and inhibited during growth factor stimulation; however, the effect of oxygen and hypoxia exposure on PTPs in the developing lung is not known. The Mathias laboratory uses a variety of cell, molecular, and animal model approaches to interrogate the role of variable oxygen tension on PTP function and early pulmonary vascular development.
Select Honors and Accomplishments:
2021 - Clinician Scientist Development Award, Presbyterian Health Foundation
2021 - Basic & Translational Research Award, Lurie Children’s Hospital
2020 - Jack Metcoff Award for Outstanding Resident or Fellow Presentation, Midwest Society for Pediatric Research
2018 - Pediatric Resident Teaching Award, Icahn School of Medicine at Mount Sinai
Select Publications:
- Mathias, M.; Chang, J.; Perez, M.; Saugstad, O. Supplemental Oxygen in the Newborn: Historical Perspective and Current Trends. Antioxidants, 2021, 10, 12, doi: https://doi.org/10.3390/antiox10121879. PMID: 34942982
- Mathias, M.; Taylor, J.; Mendralla, E.; Perez, M. Neonatal Extracellular Superoxide Dismutase Knockout Mice Increase Total Superoxide Dismutase Activity and VEGF Expression after Chronic Hyperoxia. Antioxidants (Basel) 2021, 10, 1236, doi:10.3390/antiox10081236. PMID: 34439484
- Mathias, M.; Bitar, M.; Aldulescu, M.; Birkett, R.; Perez, M.; Mestan, K. Placental Vascular Maldevelopment, Intrauterine Growth Restriction, and Pulmonary Hypertension. Pulm Circ 2020, 10, 2045894020970056, doi:10.1177/2045894020970056. PMID: 33282199